Multiscale modeling of bone tissue mechanobiology

Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and own organs. This regulatory is especially relevant for bones, given their importance as load-transmitting elements that allow movement of body well protection vital organs load impacts. Therefore bone, living tissue, continuously adapting its properties, shape repairing itself, being mechanical loads one main stimuli modulate this adaptive behavior. Here we review some key results bone mechanobiology computational models, describing effect changes associated induce response, implant design scaffold-driven regeneration.